Dynamic disease activity monitoring in Psoriatic Arthritis by novel personalized digital biomarkers*

Dynamic disease activity monitoring in Psoriatic Arthritis by novel personalized digital biomarkers* - PsAI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53819

Enrollment

120

Registered

2022-12-07

Start date

2023-01-02

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

arthritis psoriatica

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: active disease defined as not in MDA - 45 patients inactive disease defined as in MDA - 45 patients healthy controls - 30 subjects

Exclusion criteria

Exclusion criteria: other disease that linfluence movement such CVA, prostethic limb etc in patients, and sport trauma in healthy controls

Design outcomes

Primary

Measure	Time frame
Digital Measures Raw smartphone data shall be translated into behavioural vectors for physical activity, sleep and mood. Like previously done for Parkinson in i.prognosis a feature extraction and classification pipeline will be set up to classify subjects with high and low disease activity. - Keypad time-related data and metadata - Accelerometer and gyroscope sensor data - Video recordings of joint movements - Screen time Clinical Assessment: Clinical evaluation of joints, tendons and skin, inflammatory bloodmarkers (usual care), VAS global and HAQ leading to the calculation of: - Minimal disease Activity (MDA) - Psoriatic Arthritis Disease Activity Score (PASDAS) - Disease Activity Psoriatic Arthritis (DAPSA) Daily Questions Likert scale assessment within the smartphone app. will provide us with information to assess the disease symptoms over time outside the window of the clinical assessment of disease activity. - Pain. When in pain, follow-up question: did you use painkillers or NSAIDs? - Stiffness - Tiredness Amendments: none	—

Measure

Time frame

Digital Measures Raw smartphone data shall be translated into behavioural vectors for physical activity, sleep and mood. Like previously done for Parkinson in i.prognosis a feature extraction and classification pipeline will be set up to classify subjects with high and low disease activity. - Keypad time-related data and metadata - Accelerometer and gyroscope sensor data - Video recordings of joint movements - Screen time Clinical Assessment: Clinical evaluation of joints, tendons and skin, inflammatory bloodmarkers (usual care), VAS global and HAQ leading to the calculation of: - Minimal disease Activity (MDA) - Psoriatic Arthritis Disease Activity Score (PASDAS) - Disease Activity Psoriatic Arthritis (DAPSA) Daily Questions Likert scale assessment within the smartphone app. will provide us with information to assess the disease symptoms over time outside the window of the clinical assessment of disease activity. - Pain. When in pain, follow-up question: *did you use painkillers or NSAIDs?* - Stiffness - Tiredness Amendments: none

—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results