sudden cardiac death Ventricular arrhythmia
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients with a primary prevention ICD, according to current EU guidelines - Patients with no prior documented treated or untreated sustained ventricular arrhythmias - >=18 years of age
Exclusion criteria
Exclusion criteria: - Transvenous ICD implanted less than 3 months prior to inclusion - Contra-indications for venepunctures - CRT-D patients - Patients with an ICD indication based on a channelopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expression of biomarkers in the serum of patients with and without appropriate therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine novel biomarkers that may be associated with the onset of ventricular arrhythmias. This is done through proteomics. The patients with appropriate therapy are matched with patients without appropriate therapy. Subsequently, the protein profile is determined in both groups in order to see whether there are proteins that are elevated in the group with an arrhythmia and not in the group without an arrhythmia. | — |
Countries
Netherlands
Outcome results
None listed