Feasibility of the use of Ultrasound Doppler-derived patient-specific velocity profiles in fluid-structure interaction modelling of the abdominal aorta, femoral artery and carotid artery

Feasibility of the use of Ultrasound Doppler-derived patient-specific velocity profiles in fluid-structure interaction modelling of the abdominal aorta, femoral artery and carotid artery - Feasibility of the use of Ultrasound Doppler to measure velocity profiles

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53799

Enrollment

Registered

2022-06-10

Start date

2022-11-04

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

'Aneurysm' 'Dilated artery' 'Narrowed artery' 'Stenosis'

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: The main inclusion criterium for the patients is that they have an abdominal aortic aneurysm or a femoral artery or carotid artery stenosis. Furthermore, the patients should be under surveillance at the Catharina hospital for their stenosis or aneurysm. For the AAA patients, an additional inclusion criterium is that they are involved in the longitudinal study (research mentioned in B2). The volunteers should be in the age of 18-65 and not diagnosed with a cardiovascular disease.

Exclusion criteria

Exclusion criteria: Minors, incapacitated adults and mentally incompetent adults will not be included in the study. Subjects that do not want to participate will also not be included. Furthermore, also patients and volunteers that suffer from claustrophobia will be excluded from the study. Lastly, the patients and volunteers will be screened for metallic foreign bodies. In case that metallic foreign bodies are present the patients and volunteers will not be included in the study.

Design outcomes

Primary

Measure	Time frame
Patient specific velocity profile over time and cross section of the abdominal aorta, carotid artery and femoral artery obtained with Ultrasound Doppler and compared with 4D flow MRI (abdominal aorta) or 2D PCMRI (femoral and carotid artery). This patient specific velocity profile will be used in FSI simulations of AAA's, carotid artery stenoses and femoral artery stenoses.	—

Secondary

Measure	Time frame
The secondary goal of this study is to validate the FSI model. With 4D flow MRI, the velocity streamlines can be constructed, which can then be compared to the streamlines from the FSI model. In addition, based on the velocity measured with 4D flow MRI, the Wall Shear Stress (WSS) and Oscillatory Shear Index (OSI) can be calculated, which can also be compared to the WSS and OSI as predicted by the FSI model. Also the with MRI measured wall displacements will be compared to the with FSI simulated wall displacements. Lastly, the 4D flow MRI data will also be used for the validation of the stiffness of the aortic wall.	—

Measure

Time frame

The secondary goal of this study is to validate the FSI model. With 4D flow MRI, the velocity streamlines can be constructed, which can then be compared to the streamlines from the FSI model. In addition, based on the velocity measured with 4D flow MRI, the Wall Shear Stress (WSS) and Oscillatory Shear Index (OSI) can be calculated, which can also be compared to the WSS and OSI as predicted by the FSI model. Also the with MRI measured wall displacements will be compared to the with FSI simulated wall displacements. Lastly, the 4D flow MRI data will also be used for the validation of the stiffness of the aortic wall.

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Countries

Netherlands

Outcome results