acute traumatic coagulopathy Trauma-induced coagulopathy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Male - Age 18-35
Exclusion criteria
Exclusion criteria: -Participation in a scientific intervention study in the last 3 months -No informed consent -History of coagulation disorders -Active use of prescription medication -Use of anticoagulant medication, including aspirin -History of liver disease -History of chronic transmittable disease -History of alcohol, smoking or drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective 1 In vitro: what are the factors related to factor V depletion in trauma-induced coagulopathy Objective 2: In vitro: whether factor V supplementation either alone or in combination with other factors (PCC and/or fibrinogen) is associated with improvement in clot build-up determined by ROTEM | — |
Secondary
| Measure | Time frame |
|---|---|
| In vitro coagulation will be assessed through multiple methods, for example: - ROTEM - Thrombin generation assay - Platelet function (aggregometry, flow cytometry, adhesion under flow) - Plasma coagulation proteins - Blood group, Hb/HCT, platelet count | — |
Countries
Netherlands
Outcome results
None listed