Proteomics and genomics combined with CT to predict CVD

Proteomics and genomics combined with CT to predict CVD - PREDICT-CVD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53785

Enrollment

400

Registered

2022-09-21

Start date

2023-01-10

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Adult subjects between 50 and 75 years old. - Subjects at intermediate to high risk for ASCVD - Asymptomatic subjects without cardiac chest pain - Evidence of atherosclerosis on baseline CCTA

Exclusion criteria

Exclusion criteria: - Renal insufficiency, defined as eGFR

Design outcomes

Primary

Measure	Time frame
The main parameter to study will be the total coronary plaque volume progression.	—

Secondary

Measure	Time frame
• Presence of obstructive stenosis (and number of vessels) • Progression in number of significant (>50%) and severe (>70%) stenoses • Absolute total plaque volume progression (mm3) • Calcified plaque volume progression (mm3) • Non-calcified plaque volume progression (mm3) • Low-attenuation plaque volume progression (mm3) • Change in Pericoronary Adipose Tissue CT-Attenuation (HU) • CAD-RADS progression (yes/no) • Progression in number of high-risk plaque characteristics (yes/no).	—

Measure

Time frame

• Presence of obstructive stenosis (and number of vessels) • Progression in number of significant (>50%) and severe (>70%) stenoses • Absolute total plaque volume progression (mm3) • Calcified plaque volume progression (mm3) • Non-calcified plaque volume progression (mm3) • Low-attenuation plaque volume progression (mm3) • Change in Pericoronary Adipose Tissue CT-Attenuation (HU) • CAD-RADS progression (yes/no) • Progression in number of high-risk plaque characteristics (yes/no).

—

Countries

Netherlands

Outcome results