Neuroscience research brain
Conditions
Interventions
Participants will receive TUS at a standard sub-threshold intensity.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Between 18-40 years of age - Right handed - The ability and agreement to provide informed consent, and the ability to fulfil the study's requirements
Exclusion criteria
Exclusion criteria: • Under 18 years of age; • Current or planned pregnancy; • Claustrophobia; • A history or brain surgery or serious head trauma; • A history of or any close relatives (parents, siblings, children) with epilepsy, convulsion, or seizure; • Predisposition for fainting spells (syncope); • A cardiac pacemaker or intra-cardiac lines; • An implanted neurostimulator; • Implanted medication infusion device; • Implanted metal devices or large ferromagnetic fragments in the head or upper body (excluding dental wire), or jewellery/piercing that cannot be removed; • Use of a medical plaster that cannot or may not be taken off (e.g., nicotine plaster); • Cochlear implants; • Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.); • Diagnosed neurological or psychiatric disorders; • Use of psychoactive (prescription) medication (excluding anti-conception); • Skin disease at intended stimulation sites; • The consumption of more than four alcoholic units within 24 hours before participation or any alcoholic units within 6 hours before participation day; • The consumption of recreational drugs within 48 hours before participation; • Calcifications in the brain. • All other criteria relevant to non-invasive brain stimulation as reported in the Donders Standard Operating Procedures for Non-Invasive Brain Stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oculomotor behaviour (leftward/rightward saccades) in the saccade-task is used as the main outcome variable. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes, such as saccade latency and duration will also be assessed to study how TUS of the FEFs affects saccade preparation and duration. Additionally, GABA/glutamate levels in the stimulation sites (using MRS) and the intracranial stimulation intensity (calculated on each subjects structural MRI) will be examined per individual to explain any inter-individual differences in behavioural outcomes. To assess individual location of the left/right FEF and the left/right M1, which we need for stimulation during intervention sessions, we perform a short functional MRI during the intake session. Furthermore, as a quality control of this study, we have added the M1 as an active control site and we will perform a masking assessment at the end of the intervention sessions to guarantee the spatial specificity of TUS and the quality of our auditory mask, respectively. All of these measures will help ensure accuracy and precision of our findings | — |
Countries
Netherlands
Outcome results
None listed