Parkinson's disease Shaking palsy
Conditions
Interventions
The fMRI neurofeedback (NF) sessions will include anatomical scans, an fMRI
localizer (inactive bar thermometer shown whilst patients move the dominant
hand, alternating with rest periods) and neuro
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of Parkinson*s disease according to MDS clinical diagnostic criteria (Postuma et al., 2015). - Disease stage 1-3 according to the Hoehn and Yahr Scale
Exclusion criteria
Exclusion criteria: - Exclusion criteria for MRI (e.g., cardiac pacemaker, certain metallic implants) - History of psychotic disorder, bipolar disorder, or psychotic depression - Current use of illegal drugs (any in the last four weeks) - Current excessive alcohol consumption that interferes with daily functioning - Advanced cognitive impairment (MoCA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The region of interest fMRI data will be analysed with the appropriate parametric tests for activation and general linear model analysis will be performed as implemented in the Brainvoyager software. This will assess neurofeedback performance and changes in brain activation over time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlational analysis will be performed on demographic and clinical data (MoCA score) to assess association with neurofeedback performance. | — |
Countries
Netherlands
Outcome results
None listed