Effect of bullying exposure on immune-system related gene expression: A longitudinal twin study

Effect of bullying exposure on immune-system related gene expression: A longitudinal twin study - Gene expression differences in twins

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53732

Enrollment

600

Registered

2023-07-10

Start date

2023-05-01

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

low-grade inflammation mental health

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: -Twin pairs currently still enrolled in the NTR(www.tweelingenregister.vu.nl) -Being between 18-22years old (=birth cohort 2002-2006) -The twin brother or sister is also participating -Willing to complete the questionnaire and collect blood drops -Parents filled out survey when twinpair was 10 and/or 12

Exclusion criteria

Exclusion criteria: - Having an autoimmune disease - Having hyperactive thyroid - Being pregnant

Design outcomes

Primary

Measure	Time frame
Gene expression profile based on dried blood spot analysis. From the dried blood spot gene expression analysis, an a priori-specified set of 53 indicator genes (19 pro-inflammatory genes, 31 antiviral and 3 antibody-related genes) utilized in prior work to assess the CTRA will be examined (e.g., Levine et al., 2017).	—

Secondary

Measure	Time frame
Mental health (anxiety, depression, burnout) by questionnaires and physical health (body mass index, waist).	—

Countries

Netherlands

Outcome results