Ademdepressie oxycodone-induced respiratory depression respiratory depression
Conditions
Interventions
Visit A: Oxycodone 10 mg tablet at t = 0 min + pregabaline 150 mg at t = 90 min
Visit B: Oxycodone 10 mg tablet at t = 0 min + lacosamide 150 mg at t = 90 min.
Visit C (extra arm): Oxycodone 10 mg tablet at t = 0
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - aged 18-45 years, - body mass index
Exclusion criteria
Exclusion criteria: - Presence or history of any medical or psychiatric disease (incl. a history of substance abuse, anxiety, or the presence of a painful syndrome such as fibromyalgia); - Use of any medication in the three months prior to the study (incl. paracetamol or other pain killers); - Use of more than 21 alcohol units per week; - A positive urinary drug test or a breath alcohol test at screening or on the morning of the experiment; - Pregnancy, lactating or a positive pregnancy test on the morning of the experiment; - Participation in another drug trial in the 60 days prior to dosing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extrapolated ventilation at end-tidal PCO2 of 55 mmHg (VE55), 4-h following the intake of oxycodone. | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Level of sedation; (2) Relief of nociception; (3) Occurrence of nausea/vomiting; (4) pupil diameter; (5) baseline ventilation. | — |
Countries
Netherlands
Outcome results
None listed