Brain metastases
Conditions
Interventions
Not applicable.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Any histologically confirmed stage IV solid primary cancer and radiologically confirmed brain metastases; - Adult patients: >=18 years of age; - Treated with immunotherapy and/or targeted therapy (as monotherapy, combined or in combination with other treatment modalities); - Diagnosis of brain metastases >=2 years ago; - Willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: - Patients without understanding of the Dutch language, hampering the completion of questionnaires or undergoing neurocognitive testing; - Patients with a poor physical condition or any psychiatric condition or cognitive impairment, as determined by the treating physician, that will hamper them to provide consent to research or undergo neurocognitive testing or completion of the questionnaires.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Neurocognitive functioning - Instrumental activities of daily living - Health-related quality of life - Epilepsy - Radiological abnormalities (cerebral abnormalities and treatment-induced radiological abnormalities) | — |
Secondary
| Measure | Time frame |
|---|---|
| Sociodemographic information (i.e. age at study assessments, gender, level of education, marital status and living arrangements, current or last profession) and clinical information (Karnofsky Performance Status, date of diagnosis primary cancer, relevant histological and molecular tumor information, sites of metastases, date of diagnosis brain metastases, number and location of brain metastases, previously received anti-tumor treatment and anti-tumor treatment at assessment, corticosteroid and antiepileptic drug use, and comorbidity). | — |
Countries
Netherlands
Contacts
Public ContactA. Welle e.v. Preesman
Leids Universitair Medisch Centrum
Outcome results
None listed