sarcomas Soft tissue sarcomas
Conditions
Interventions
None listed
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Histologically confirmed soft tissue sarcoma for which the standard treatment includes RT (deep seated and/or >= 5 cm in largest tumor diameter and/ or an anticipated close resection margin and/or grade II/III according to the FNCLCC definition); • The sarcoma mass need to be located in an extremity; • Able and willing to undergo radiotherapy; • Able and willing to comply with the drawing of blood samples; • Age >= 18 years; • Adequate organ function at start of radiotherapy as defined in Table 4; • Signed written informed consent prior to any study specific procedures or sampling;
Exclusion criteria
Exclusion criteria: • Patients with recurrent sarcomas who underwent prior RT to the target lesion (if the primary sarcoma was managed by surgery only and no perioperative RT, patients are eligible); • Ewing sarcoma and other PNET family tumors, rhabdomyosarcomas, bone sarcomas; • Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol; those conditions should be discussed with the patient before registration in the trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of ALT or AST elevations (all grade) in STS patients receiving RT of the extremities. | — |
Secondary
| Measure | Time frame |
|---|---|
| The prevalence of DNA-damage in peripheral blood mononuclear cells | — |
Countries
Netherlands
Outcome results
None listed