Protocol development for a Very Low Field (0.047 T) MRI system

Protocol development for a Very Low Field (0.047 T) MRI system - Very low field MRI protocol development

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53693

Enrollment

276

Registered

2022-12-28

Start date

2024-06-03

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N.A. N.A.

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers between the age >18 years or

Exclusion criteria

Exclusion criteria: - Age 65 years - Persons with reduced mental capacity - Pregnancy and a chance of being pregnant (as reported by the volunteer) - Not having a general practitioner - MRI contraindication e.g. cardiac pacemaker, implants not approved for MRI (see www.mrisafety.com), claustrophobia, tinnitus.Decision on the MRI contraindication is made according to the guidelines outlined in the MR safety document of the Department of Radiology which can be found in the attachment (*MRI Veiligheidsrichtlijnen LUMC (BPPC-protocol)*).

Design outcomes

Primary

Measure	Time frame
The first study parameters of this project are quantitative measurements of MR image quality with respect to the commercial Hyperfine system which operates at a similar field strength. Specifically, we will compare T1, T2, T1, T2, magnetisation transfer and diffusion images in the brain, since these are the quantities that are in the approved Hyperfine protocol. From this data, we will perform quantitative analysis (signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR)). In addition, we will develop sequences to look at fat/water imaging in the human calf muscle/forearm (these cannot be performed on the Hyperfine system since the closed geometry of the RF coil only allows brain imaging). The second aim is to investigate a number of different types of image processing on the image quality, since with our self-developed system we have complete access to the raw data being acquired. We will quantitate improvements in image quality in terms of SNR measurements, as well as scoring from our (neuro)radiologists.	—

Measure

Time frame

The first study parameters of this project are quantitative measurements of MR image quality with respect to the commercial Hyperfine system which operates at a similar field strength. Specifically, we will compare T1, T2, T1*, T2*, magnetisation transfer and diffusion images in the brain, since these are the quantities that are in the approved Hyperfine protocol. From this data, we will perform quantitative analysis (signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR)). In addition, we will develop sequences to look at fat/water imaging in the human calf muscle/forearm (these cannot be performed on the Hyperfine system since the closed geometry of the RF coil only allows brain imaging). The second aim is to investigate a number of different types of image processing on the image quality, since with our self-developed system we have complete access to the raw data being acquired. We will quantitate improvements in image quality in terms of SNR measurements, as well as scoring from our (neuro)radiologists.

—

Secondary

Measure	Time frame
None	—

Countries

Netherlands

Contacts

Public ContactC F Najac

Leids Universitair Medisch Centrum

c.f.najac@lumc.nl+31 6 24870692

Outcome results