fatty liver disease hepatic steatosis
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age >= 45 years and 27 kg/m2) - Males and postmenopausal females - Caucasian - Hepatic steatosis defined as increased hyperechogenicity of the liver on abdominal ultrasound, CAP score on Fibroscan > 280, and/or histological signs of steatosis - Sedentary lifestyle (maximum of 20*minutes of moderate-to-vigorous physical activity per day on less than three days per week) - Written informed consent
Exclusion criteria
Exclusion criteria: - Exclusion criteria for MRI (claustrophobia, pacemaker, metal implants, etc.) - Any other liver disease than NAFLD/NASH - Present excessive alcohol use defined as > 2 units/day - Recent use (5%) - Recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is the reduction of liver fat levels and other markers of NAFLD after 12 weeks of morning or evening exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include the improvement of insulin resistance, circulating levels of liver enzymes, fitness, and gut microbiota composition in response to morning or evening exercise. | — |
Countries
Netherlands
Outcome results
None listed