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ABC study

Appropriate use of Blood Cultures in the emergency department through machine learning: a randomized controlled trial. - ABC Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON53669
Enrollment
2894
Registered
2023-08-11
Start date
2024-02-27
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacteraemia Bloodstream infection

Interventions

The use of the blood culture prediction model, to omit blood cultures analyses&nbsp
at less than 5% chance of a positive culture.

Sponsors

Amsterdam UMC
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All adult patients who have a clinical indication for a blood culture analysis (according to the treating physician) in the emergency department.

Exclusion criteria

Exclusion criteria: • Central Venous Line (CVL) or Peripherally Inserted Central Catheter (PICC) in situ. • Neutrophil count < 0.5 * 109/L • Candidemia or S. aureus bacteraemia in the past 3 months • A high suspicion of endocarditis/spondylodiscitis/infected prosthetic  material/bacterial meningitis • Pregnant or breastfeeding patients • Patient returning to ED due to positive blood culture

Design outcomes

Primary

MeasureTime frame
Non-inferiority regarding 30-day mortality.

Secondary

MeasureTime frame
The key secondary outcomes are: Non-inferiority regarding hospital admissions, length of stay in hospital and death in hospital. Furthermore, superiority is examined in a large group of different outcome measures (either patient-, process- or model-related).

Countries

Netherlands

Contacts

Public ContactK.D.P.B. Nanayakkara

Amsterdam UMC

p.nanayakkara@amsterdamumc.nl020 444 4444

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Apr 17, 2026