bipolar disorder
Conditions
Interventions
This is not an interventional study.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Aged 18 years or aboveClinically diagnosed with bipolar disorder type I or II and confirmed BD diagnosis according to the CIDI Starting lithium treatment as part of their regular treatmentWritten informed consent
Exclusion criteria
Exclusion criteria: Participants who cannot read, speak or understand Dutch Unable to provide informed consent: this will be assessed during the informed consent procedure by trained research personnel. When in doubt, they will be able to consult a clinician.Drug or alcohol abuse over a period of 2 weeks prior to the experimentContra-indications for an MRI/MRSI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the clinical response to lithium treatment at 1 year follow-up, assessed using a validated questionnaire. Linear regression analysis will be used to establish correlations between brain lithium concentrations—measured through mean brain, voxel-wise, parcellation, and region-of-interest approaches—and clinical lithium response. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum lithium levels: correlations with mean brain lithium concentrations will be determined. | — |
Countries
Netherlands
Contacts
Public ContactE Boere
Leids Universitair Medisch Centrum
Outcome results
None listed