Multiple Sclerosis Multiple Sclerosis
Conditions
Interventions
MRI
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: To be eligible for this study, the participant must meet the following criteria: Diagnosed as CIS, RRMS, PPMS based on McDonald criteria (2017) Adult (18-70 years old) Signed informed consent Separate inclusion criteria will be applied for the active and inactive subgroup: For the active subgroup: one or more Gd-enhancing lesion on brain MRI or signs of clinical disease activity For the inactive subgroup: no Gd enhancing lesion on brain MRI and no clinical signs of disease activity.
Exclusion criteria
Exclusion criteria: A potential participant will be excluded from the study based on the following criteria: contra-indications for MRI Pregnancy History of (psychiatric) disorder which causes the patient to be incompetent to make a well-informed decision Other concurrent neurological disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Establishing differences in image characteristics of Gd enhancing and non-enhancing lesions on the advanced MRI sequences. 2) Establishing differences in image characteristics on the advanced MRI sequences between new lesions and previously present lesions. 3) Establishing differences between blood biomarker levels between participants with and without Gd enhancing lesions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Contacts
Public ContactE. Donders
Amsterdam UMC
Outcome results
None listed