n.v.t. gut bacteria microbiota
Conditions
Interventions
Subjects receive 1 sachet of GOS (1.3 or 2 grams) per day. They have to
dissolve this in a product of their choice (water, yogurt, milk, tea, coffee,
custard) at breakfast. Subjects are instructed t
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Apparently healthy women (based on screening questionnaire), living in the surrounding of Wageningen (+50 km ) - Aged between 40 - 70 year - Body Mass Index (BMI) between 18,5 - 30 kg/m2
Exclusion criteria
Exclusion criteria: - Having a gastro-intestinal disease, such as celiac disease, Crohn*s disease, Ulcerative colitis, or diagnosed irritable bowel disease; - Having a history of intestinal surgery that might interfere with study outcomes. This does not include an appendectomy or cholecystectomy; - Diagnosed with diabetes mellitus; Use of medication that may influence the study results, such as laxatives, lactase preparations, metformin, antibiotics, proton pomp inhibitors, antipsychotics, NSAID*s (judged by our research physician); - Self-perceived or diagnosed constipation; - Having a food allergy to cow*s milk or being lactose intolerant; - Reported slimming, medically prescribed or other diets - Reported weight loss or weight gain of >5kg in the month prior to screening - Use of pre-, pro- , syn- and/or postbiotics (should be stopped at least 4 weeks before the start of the study), or other supplements that can influence the study results (to be determined by the medical investigator); - History of side effects with the use of prebiotic supplements - Use of antibiotic treatment less than 3 months before start of the study - Pregnant or lactating (or having the wish to become pregnant during the study period, self-reported); - Not able to comply with study procedures; - Abuse of drugs (should be stopped at least 4 weeks before the study); - Alcohol intake >=7 glasses of alcoholic beverages per week, on average - Participation in another clinical trial at the same time; - Being an employee of the Food, Health & Consumer Research group of Wageningen Food & Biobased Research or employee of FrieslandCampina R&D.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the absolute abundance of faecal Bifidobacterium. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are faecal microbiota composition. Tertiary Objectives are gastrointestinal (GI) comfort, sleep quality (Athens Insomnia scale), well-being and stress (DASS-21). | — |
Countries
Netherlands
Outcome results
None listed