mental disorders psychiatric disorders
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy cohort: - Volunteer aged 16-80, who has participated in prior studies at the Donders Centre for Cognitive Neuroimaging and for whom neuroimaging data are available (see protocol for details) - Has provided consent to be re-contacted for future research - Possesses and uses an Android smartphone (required for the BeHapp software) Patient cohort: - Volunteer who has participated in the MIND-Set 2 study. This means the subject is: -- Adult (age >=16) in- and outpatient at the Department of Psychiatry of the Radboudumc -- Referred for a diagnostic and/or treatment question relating to either stress-related (mood, anxiety), neurodevelopmental (ASD, ADHD, personality) and/or impulse-regulation disorders. These criteria are assessed by the clinician during the intake interview, and will be confirmed through detailed diagnostic interviews. - Has provided consent to be contacted about participation in other studies. - Possesses and uses an Android smartphone (required for the BeHapp software)
Exclusion criteria
Exclusion criteria: - Cannot speak, read and/or understand Dutch (VMBO level) and English (working profiiency) - Prior history of significant neurological illnesses - Pregnancy - Standard contra-indication for MRI: -- unsafe metal or devices in the body (Cardiac Pacemaker, cochlear implant, aneurism clip) -- previous brain surgery -- moderate to severe claustrophobia Additional exclusion criteria for healthy controls: - Current disease that affects the brain - Prior history of significant psychiatric illness - Neurological disorders of the central nervous system - Fifteen or more units of alcohol per week - Recreational drug use of once or more per week - Benzodiazepine use of once or more per week - Malignancies - Rare, chronic somatic disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Behavioural phenotypes derived from fitting a machine learning models (e.g. hidden Markov models) to timeseries of smartphone sensor data provided by the BeHapp platform. - Parameters from multi-modal neuroimaging data from healthy individuals and individuals with mental disorders (e.g. measures of cortical thickness derived from structural MRI, functional connection strength derived from resting state fMRI). - cross-diagnostic symptom scores across different functional domains (latent factor scores derived from a factor analysis). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Subject-level deviation maps derived from normative models of neuroimaging-based measures and behavioural phenotypes derived from smartphone measures (e.g. subject level Z-statistic images) - Measures of subject-level overlap across these measures | — |
Countries
Netherlands
Outcome results
None listed