Asthma
Conditions
Interventions
Standard care
• Consult pulmonary physician
• Blood sampling
• Spirometry
• Visual Analogue Scale (VAS) and Asthma Quality of Life Questionnaire (AQLQ)
• Asthma Control Questionnaire (ACQ)
Visit 1
Sponsors
Franciscus Gasthuis & Vlietland
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Patients >= 18 years, referred by the general practitioner to the outpatient clinic pulmonology with the suspicion of asthma • Patients without reversibility at the spirometry (delta FEV1 >= 200 ml and >=12% improvement) • Patients understand the Dutch or English language for giving informed consent and to complete the questionnaires • They can discontinue their medication (discontinuation time depends on the kind of medication, paragraph 3.2)
Exclusion criteria
Exclusion criteria: Patients will be excluded if: • They have a fixed obstruction or with already the diagnose with asthma based on prior tests • They are pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study endpoint: • (Theoretical) reduction of BPTs | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: • Direct healthcare costs of diagnosis (avoidable BPTs, extra costs of FeNOs, extra diagnose costs in FeNO >= 50 ppb and negative BPT) • The diagnostic burden of FeNO testing and BPT testing (VAS -score and AQLQ) • Asthma control (ACQ) Secondary parameters: - Patient characteristics - Asthma profile (eosinophils, sIgE to inhalation allergens) - Lung function (FEV1 and Forced Vital Capacity (FVC) and FVC/ FEV1) - Outcome BPT (positive/negative) - FeNO test outcome (ppb) | — |
Countries
Netherlands
Outcome results
None listed