letsel - bloeduitstortingen bruises hematomas
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age 18 years or older • Competent • Sufficient Dutch/ English proficiency • Visible bruises caused by external force • Clear knowledge and preferably proof of the date and time the injury has been sustained • Informed consent to undergo a skin biopsy and donate the material
Exclusion criteria
Exclusion criteria: • Location of the bruise in the face/ hands/ feet • Pre-existing inflammatory skin disorders such as psoriasis, SLE and dermatitis • History of keloid formation or hypertrophic scar formation • Relevant medication use such as anticoagulation drugs • Skin injury such as lacerations • Underlying fractures of bone • Sexual assault • Serious emotional/ mental disturbance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of protein markers in superficial layers of the skin (epidermis and superficial dermis), detected and measured by immunohistochemical analysis in skin biopsies from bruises as follows: - the quantity of the protein marker or an (intensity) score reflecting the presence/ absence of the protein marker and, - the cellular location (keratocytes, fibroblasts or extracellular matrix) of each marker | — |
Countries
Netherlands
Outcome results
None listed