Heading in football: impact on neural blood biomarkers

Heading in football: impact on neural blood biomarkers - HEADLINE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53582

Enrollment

280

Registered

2023-07-26

Start date

2024-08-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain damage Neurodegeneration

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Member of the KNVB - 18 years or older - Male - Self-reported fitness to play 70-90 minutes

Exclusion criteria

Exclusion criteria: - Sustained a head injury in the last year - History or current neurological condition - Regular participation in other contact sports (e.g. rugby, American football, ice hockey, fighting sports) - (Former) military personnel with a history of fighting/blast exposure

Design outcomes

Primary

Measure	Time frame
The main study parameter is the change in concentration of neurofilament light after playing a football match with naturalistic heading exposure.	—

Secondary

Measure	Time frame
The secondary study parameters are the change in concentration of GFAP, p-Tau, S100B, NSE and beta-synuclein in blood after playing a football match with naturalistic heading exposure. Other study parameters are demographic variables, medical history, heading characteristics, exercise intensity, and genetic risk factors for neurodegenerative disease.	—

Countries

Netherlands

Outcome results