BRIDGE - Parental and Offspring Brain Imaging in families at risk for severe mental illness

BRIDGE - Parental and Offspring Brain Imaging in families at risk for severe mental illness - BRIDGE-Parental and Offspring Brain Imaging (BRIDGE-POBI)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53543

Enrollment

400

Registered

2022-11-24

Start date

2023-07-26

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar disorder manic-depressive disorder Schizophrenia Schizophrenic disorder Bipolar disorder manic-depressive disorder Schizophrenia Schizophrenic disorder

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Previously-included offspring: All offspring who participated in the BRIDGE cohort are eligible for inclusion in this MRI study. Offspring will now be 14 years and older. The only other inclusion criterion is ability to provide informed consent. Parents: All biological parents of offspring who participated in the BRIDGE cohort are eligible for inclusion in this MRI study. The only other inclusion criterion is ability to provide informed consent. Newly-included offspring: All biological offspring who did not previously participate in the BRIDGE cohort are eligible for inclusion in this MRI study. As this will be their first assessment, subjects will have to satisfy the following criteria in order to participate in the study: -from 8 years and older -provide written informed consent (by child and/or parents) -Dutch speaking - IQ > 70

Exclusion criteria

Exclusion criteria: Previously-included offspring, newly-included offspring, and parents: - contraindication for MRI (including claustrophobia, a cardiac implantable electronic device, ferromagnetic metal implants, piercing (in some cases), tattoos (in some cases)) (Ghadimi & Sapra, 2022); - not having given permission to be approached for further research during an earlier assessment. - history of closed- or open-head injury - history of neurological illness - major medical history - history of epilepsy

Design outcomes

Primary

Measure	Time frame
- Brain volume, cortical thickness, cortical surface, curvature/gyrification metrics (global measures and local regions) from T1 weighted images. - Fractional anisotrophy, mean diffusivity, axial diffusivity, radial diffusivity (per fiber and voxelbased) from DTI images. - Brain activation during resting state (per region and voxelbased) from rsfMRI images. - Graph theory metrics from FA (DTI) and resting state brain activation (rsfMRI).	—

Measure

Time frame

- Brain volume, cortical thickness, cortical surface, curvature/gyrification metrics (global measures and local regions) from T1 weighted images. - Fractional anisotrophy, mean diffusivity, axial diffusivity, radial diffusivity (per fiber and voxelbased) from DTI images. - Brain activation during resting state (per region and voxelbased) from rsfMRI images. - Graph theory metrics from FA (DTI) and resting state brain activation (rsfMRI).

—

Secondary

Measure	Time frame
The following variables are seen as possible confounding or modifying factors: - sex and age - age of onset parental and offspring disorder - marital and/or household status of parents - income and educational level of parents - parental psychosis, depression, and/or mania diagnoses and symptoms - medication use - handedness	—

Countries

Netherlands

Contacts

Public ContactN.E.M. Haren

Erasmus MC, Universitair Medisch Centrum Rotterdam

bridge@erasmusmc.nl010-7036083

Outcome results