sickle cell anemia Sickle cell diseae
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
No minimum to 11 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of SCD (SCD group); - Age 6 - 24 months old; - Inhabitant of the Netherlands; - Written informed consent from parent/caretaker;
Exclusion criteria
Exclusion criteria: - Refused informed consent from parents/care-taker; - Diagnosis of visual impairment; - Diagnosis of a (co-morbid) congenital developmental condition - Any neurological condition, unrelated to SCD, that could affect the central nervous system, such as brain trauma, epilepsy and meningitis/encephalitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early identification of children with SCD at risk of impaired neurocognitive development. Eye-tracking will be performed to assess neurocognitive development. | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify determinants (risk and protective factors) and biomarkers of early neurocognitive deficits in children with SCD, by looking at socio-economic status and biomarkers. Next to this, the relationship between early neurocognitive functioning and adaptive daily life functioning later in life will be analysed, by looking at the quality of life, the behavioural and emotional functioning and general development. | — |
Countries
Netherlands
Outcome results
None listed