Comparison of prenatal and postnatal cardiac function assessed by echocardiography using pulsed wave Doppler, Tissue Doppler and speckle tracking (strain and strain rate) between foetuses/neonates with a structural heart disease, with an fetal growth restriction (FGR) and healthy fetuses/neonates

Comparison of prenatal and postnatal cardiac function assessed by echocardiography using pulsed wave Doppler, Tissue Doppler and speckle tracking (strain and strain rate) between foetuses/neonates with a structural heart disease, with an fetal growth restriction (FGR) and healthy fetuses/neonates - STIPP-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53531

Enrollment

235

Registered

2021-12-20

Start date

2022-09-12

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Structural heart disease (congenital heart defect). Fetal growth restriction.

Interventions

Not applicable.

Eligibility

Inclusion criteria

Inclusion criteria: - Informed consent - Sufficient command of the Dutch language - A pregnancy with a fetus with a structural heart disease, or - A pregnancy with a fetus with an FGR (defined as: weight and/or abdominal circumference p 20 percentiles, and Doppler abnormalities in either the umbilical artery, the uterine artery or the medial cerebral artery), or - A pregnancy with a healthy fetus (without any major fetal congenital abnormality)

Exclusion criteria

Exclusion criteria: - Multiple pregnancy - A pregnancy with known fetal genetic abnormality - A pregnancy with other major fetal congenital abnormalities

Design outcomes

Primary

Measure	Time frame
Comparison of fetal systolic and diastolic function in fetuses with a structural heart disease, fetuses with an FGR and healthy fetuses, using (blood) speckle tracking, pulsed waved Doppler and tissue Doppler, at multiple time points in the pregnancy and within 72 hours postpartum.	—

Secondary

Measure	Time frame
Technical feasibility of cardiac function measurements by means of fetal echocardiography using speckle tracking, pulsed waved Doppler and tissue Doppler in fetuses with a structural heart disease. This includes the comparison of two software*s used to evaluate cardiac deformation (TOMTEC and Voluson Fetal HQ) by speckle tracking and the additional value of fetal electrocardiogram during cardiac function measurements and the optimization of the used techniques.	—

Measure

Time frame

Technical feasibility of cardiac function measurements by means of fetal echocardiography using speckle tracking, pulsed waved Doppler and tissue Doppler in fetuses with a structural heart disease. This includes the comparison of two software*s used to evaluate cardiac deformation (TOMTEC and Voluson Fetal HQ) by speckle tracking and the additional value of fetal electrocardiogram during cardiac function measurements and the optimization of the used techniques.

—

Countries

Netherlands

Contacts

Public ContactJ.M.J. Cornette

Erasmus MC, Universitair Medisch Centrum Rotterdam

s.vandenwildenberg@erasmusmc.nl010-704 07 04

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Feb 7, 2026