Postponing cognitive decline and preventing early unemployment in patients with multiple sclerosis - strengthening the brain and mind (part of the Don't be late! study)

Postponing cognitive decline and preventing early unemployment in patients with multiple sclerosis - strengthening the brain and mind (part of the Don't be late! study) - Don't be late! WP 2 and 3

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON53491

Enrollment

270

Registered

2023-04-12

Start date

2023-04-16

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MS Multiple Sclerosis MS

Interventions

*Strengthening the brain* (4 month-program) consists of weekly 30 minutes&nbsp

1-on-1 exercise and lifestyle coaching in combination with two moments per week&nbsp

unsupervised exercises at home and a home-based online computerized cognitive&nbsp

training. *Strengthening the mind* (4 month-program) consists of biweekly&nbsp

contact with work coaches who are all diagnosed with MS themselves.

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Confirmed MS diagnosis according to McDonald 2017 criteria - Age between 18 and 67 - No changes in disease modifying therapy prior to inclusion (i.e. no changes in last 3 months) - No current relapse or steroid treatment in the six weeks prior to the study visits - Sublinical cognitive impairment

Exclusion criteria

Exclusion criteria: - Patients with neurological (other than MS) and psychiatric disorders - A current or history of drug or alcohol abuse - Being unable to speak or read in Dutch - Currently on sick leave and working for less than 12 hours for a period of 3  months or longer

Design outcomes

Secondary

Measure	Time frame
Changes in cognitive performance (as measured with the neuropsychological examination) will serve as secundary parameter. Additionally, changes on questionnaires (concerning neuropsychological symptoms, work challenges and participation, fatigue, anxiety and depression, resilience, stress and worry, ability to participate in social roles and activity) will be included. Brain changes will also be observed using MRI.	—

Measure

Time frame

Changes in cognitive performance (as measured with the neuropsychological examination) will serve as secundary parameter. Additionally, changes on questionnaires (concerning neuropsychological symptoms, work challenges and participation, fatigue, anxiety and depression, resilience, stress and worry, ability to participate in social roles and activity) will be included. Brain changes will also be observed using MRI.

—

Primary

Measure	Time frame
The primary outcome is change in quality of life as measured with the 36-item Short Form.	—

Countries

Netherlands

Contacts

Public ContactSRD SRD

Amsterdam UMC

s.saddal@amsterdamumc.nl0622116891

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Mar 20, 2026