lichamelijk trauma na ongeval Injury Trauma
Conditions
Interventions
Restrictive (intervention) versus liberal (control) oxygen treatment.
Sponsors
Rigshospitalet Kopenhaben
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged >=18 years, including fertile women* 2) Blunt or penetrating trauma mechanism 3) Direct transfer from the scene of accident to one of the participating trauma centres 4) Trauma team activation (basic or extended trauma team) 5) The enrolling physician must initially expect a hospital length of stay for 24 hours or longer 6) Deferred consent by patient or proxy
Exclusion criteria
Exclusion criteria: 1) Patients in cardiac arrest before or on admission 2) Patients with a suspicion of carbon monoxide intoxication 3) Patients with no/minor injuries after secondary survey will be excluded if they are expected to be discharged
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure will be a combined endpoint of 30-day mortality and/or major respiratory complications (pneumonia and ARDS) within 30 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures will be mortality at 30 days and 12 months after trauma, major respiratory complications (pneumonia and ARDS) within 30 days, hospital length of stay (HLOS), Intensive Care Unit length of stay (ICU LOS) and days alive outside the ICU, time on mechanical ventilation (until 30 days), days alive without mechanical ventilation and number of re-intubations within 30 days, pneumonia post-discharge within 30 days, episodes of hypoxaemia during intervention (saturation | — |
Countries
Netherlands
Outcome results
None listed