Small fiber neuropathy
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Definite small fiber neuropathy (SFN): a) Subjects of 18 years and older b) Clinical symptoms and signs of SFN c) Abnormal intraepidermal nerve fiber density (IENFD) in skin biopsy of the distal leg d) Subjects must give informed consent by signing and dating an informed consent form Probable SFN: a) Subjects of 18 years and older b) Clinical symptoms and signs of SFN c) Normal IENFD in skin biopsy of the distal leg d) Abnormal quantitative sensory testing (QST) e) Subjects must give informed consent by signing and dating an informed consent form
Exclusion criteria
Exclusion criteria: a) Signs of large nerve fiber neuropathy in neurological examination (weakness, loss of vibration sense, hypo-/areflexia) b) Abnormal nerve conduction studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is an electronic web-based registry, which reflects the natural course of SFN and change over time in the diagnostics of SFN. Changes in neurological examination, nerve conduction studies, IENFD, quantitative sensory testing and their relation to SFN-related symptoms, daily functioning and QoL will be demonstrated. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint is if and what diagnostics could ultimately be used in future trials. | — |
Countries
Netherlands
Outcome results
None listed