pulmonary fibrosis - connective tissue formation in the lungs
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male patients 18 years or older and female patients 20 years or older, discharged from hospital after PCR-confirmed COVID-19. - Previous ICU and/or ward admission with high flow nasal oxygen (HFNO) or mechanical ventilation. - Persistent respiratory complaints at least 3 months after discharge (shortness of breath). - Registered diffusing capacity for carbon monoxide (DLCO) and vital capacity (VC).
Exclusion criteria
Exclusion criteria: - Inability or unwilling to give informed consent. - History of claustrophobia or feeling of inability to tolerate supine position for the PET/CT scans. - Severe or significant comorbidityI, defined as COPD GOLD stage II or higher, known interstitial lung disease and/or an ASA score of IV or higher. - Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fibroblast activity measured by FAPI-PET/CT | — |
Secondary
| Measure | Time frame |
|---|---|
| - Interstitial lung abnormalities (ILA) on high resolution computed tomography (HRCT) - 6-minute walking test (6MWT) - Inflammatory and fibrosis blood markers - Self reported daily impairments (EQ5D questionnaire) | — |
Countries
Netherlands
Outcome results
None listed