Muscle disorders
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with sarcopenia. In order to be eligible to participate in this study, a participant must meet the following criteria: • Non-hospitalized individuals • Ability to follow test instructions • Age above 65 years • Diagnosed with Sarcopenia according to the SARC-F questionnaire and handgrip Strength Patients with neuromuscular diseases In order to be eligible to participate in this study, a patient must meet the following criteria: • Confirmed NMD diagnosis • Referral to supervised exercise rehabilitation program • Ability to follow test instructions • Non-hospitalized individuals • Age > 18 years Athletes with hamstring injury In order to be eligible to participate in this study, an athlete must meet the following criteria: • Anamnestic pain in posterior thigh • Localised pain during palpation of hamstring muscle • Localised pain during passive straight leg raising • Increasing pain during isometric contraction • Age> 18 years old Control participants In order to be eligible to participate in this study, a participant must meet the following criteria: • Non-hospitalized individuals • Ability to follow test instructions • Age> 18 years
Exclusion criteria
Exclusion criteria: • Inability to provide informed consent • Have a history of claustrophobia • Patients/ participant is not eligible to perform the exercise test described in this study protocol or follow instructions • Contra-indication for MRI (e.g., pacemaker, Claustrophobia; See F1 vragenlijsten screening MRI Amsterdam UMC) • Muscle injury in the 6 months prior to participation in this study (Except for the athletes) • Being under investigation for non-diagnosed disease at the time of investigation • Risk factors for exercise testing registered by a Dutch version of the pre-participation questionnaire (American college of sports medicine and American Heart association). Possible risk factors will be discussed with a medical specialist or general practitioner before a subject can be included. Specific exclusion criteria for adults with Neuromuscular disease • Engaged in an exercise program for a period longer than 4 weeks in the past 6 months. • Participants with variably of rapidly progressive NMD, characterized by muscle impairment that worsens over months, e.g. amyotrophic lateral sclerosis. • Participants who are not stable on medication. • Participants with cardio-pulmonary involvement. Specific exclusion criteria for Athletes with hamstring injury: • Cause of the hamstring injury is an extrinsic trauma of the posterior thigh • Patient does not have the intention to return to full sports activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For the muscle oxidative capacity the main endpoints are the repeatability of/ and sensitivity to changes in high-energy phosphate metabolites, including adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi), myofiber pH and T2* relaxation times measured at rest, during a supine cycling test and during recovery. The main endpoints for the assessment of muscle contractile function are the feasibility of/ repeatability of/ and sensitivity to changes of the strain rate and strain rate distributions along and perpendicular to the fibers measured during knee-flexion & -extension exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters: • Muscle Morphology measures using qMRI (Muscle volumes; Fat fractions; architectural parameters, diffusion measures; water T2 relaxation times) • Hand grip strength • Motor function tests (e.g. KATZ score, SPPB, IADL, TUG) • BMI (height & weight) • Blood pressure • 7-day Activity levels • Questionnaires (e.g. fall history, co-morbidities(CIRS), mental functioning (MOCA), daily life activities (IPAQ), feasibility of the in-magnet exercises) | — |
Countries
Netherlands
Outcome results
None listed