insulin resistance Muscle loss
Conditions
Interventions
A single test day during which participants will orally ingest a dietary
supplement containing all amino acids (FullAA) or a supplement containing all
amino acids but BCAAs (NoBCAA). Continuous intr
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Aged from 18-35 years • 18.5
Exclusion criteria
Exclusion criteria: • Smoking • Diabetes (Type 1, Type 2, or genetic form of diabetes) • Any diagnosed cardiovascular (heart) disease or high blood pressure (>=140 mmHg systolic and/or >=90 mmHg diastolic) • Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) • Known allergy to lidocaine • Prone to keloid forming (i.e. hyperplastic growth of scars). • Regular use of dietary protein and/or amino acid supplements (>3 times per week) • Currently involved in a structured progressive resistance training programme (>3 times per week) • A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia. • Any previous motor disorders or disorders in muscle and/or lipid metabolism • Presence of an ulcer in the stomach or gut and/or strong history of indigestion • Known severe kidney problems • Pregnant or breastfeeding • Unable to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle protein synthesis rates, expressed as fractional synthetic rate (FSR), in the basal and postprandial state. | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle glucose uptake (i.e. direct measure of muscle insulin sensitivity). Fat and fat-free mass (via DXA scan) | — |
Countries
Netherlands
Outcome results
None listed