coronary artery disease myocardial perfusion
Conditions
Interventions
None listed
Sponsors
Nucleaire Geneeskunde en Moleculaire Beeldvorming
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: o Healthy subjects: * Aged above 40 years * Male or female * Good general health * Height 1.60 m - 1.85 m * BMI 20-25 kg/m2 * Informed consent signed o Patients suspected or known with Coronary Artery Disease: * Aged above 40 years * Male or female * Height 1.60 m - 1.85 m * Diagnosed or suspected with Coronary Artery Disease * Informed consent signed
Exclusion criteria
Exclusion criteria: o Healthy subjects: * Clinical history of diabetes, hypertension, dyslipidemia * History of cardiac disease * Family history of Coronary Artery Disease * Active or short history of cigarette smoking * Inability or unwillingness to give informed consent * Known hypersensitivity to adenosine * Clinical active bronchospasm * Chronic obstructive pulmonary disease or asthma * Chronic kidney disease * Expressed willing to not continue with the participation * Pregnancy or breastfeeding * Claustrophobia * Not able to cycle o Patients suspected or known with Coronary Artery Disease: * Known hypersensitivity to adenosine * Bundle branch block * Presence or temporal or definitive pacemaker * Presence of heart valve prosthesis, shoulder prosthesis, prosthetic reconstruction of the chest wall or other prosthetic devices within the field of view * Clinical active bronchospasm * Chronic obstructive pulmonary disease or asthma * Expressed willing to not continue with the participation * Pregnancy or breastfeeding * Claustrophobia * Not able to cycle
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main parameters to measure are regional and global MBF and CFR during rest and stress with the different proposed stressors: adenosine, breath-holding manoeuvre, Valsalva manoeuvre and bicycle exercise. MBF will be calculated by a research dedicated software (Carimas) in ml/g/min based on 15O-H2O Total-body PET/CT acquisitions. CFR will be calculated as the ratio of stress MBF and rest MBF. CFR=(stress MBF)/(rest MBF) Data of myocardial perfusion will be analysed to address the feasibility of breath-holding manoeuvre, Valsalva manoeuvre and bicycle exercise as stress myocardial perfusion test during 15O-H2O Total-body PET/CT. Adenosine stress serves as the reference method.3330 Final values in these parameters will be reported for all the cohorts in a descriptive manner: -Normally distributed quantitative variables will be presented with mean, standard deviation and 95 % confidence interval. -Non-normally distributed data will be presented with median and interquartile range. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary parameters will be measured by rest and stress phases (with adenosine stress and with the different proposed stressors: breath-holding manoeuvre, Valsalva manoeuvre and bicycle exercise): • CBF is the blood volume that flows per unit per mass per unit in time in brain tissue calculated by a software (PMOD) and expressed in ml/g/min based on 15O-H2O Total-body PET/CT acquisitions. • RBF and SBF refer to the blood volume that flows to the kidneys and to the spleen respectively. These measurements are expressed in ml/g/min and will be calculated using dedicated software (PMOD) based on 15O-H2O Total-body PET/CT dynamic images. Quantitative descriptive analysis will be performed to report the performance of CBF, RBF and SBF in rest and during physiological and adenosine stress. | — |
Countries
Netherlands
Outcome results
None listed