High blood pressure Hypertension Non-alcoholic fatty liver disease
Conditions
Interventions
Per visit, participants are provided a food product containing 20 g fructose.
This amount of fructose resembles a physiological intake of fructose.
The four fructose-containing food products includ
Jonagold apple, peeled and cored. A validated enzymatic assay (Enzytec* Generic
D-Glucose/D-Fructose/Sucrose #E1247, R-Biopharm® AG, Darmstadt Germany) is used
to measure fructose content of every i
Long shelf life, store bought apple juice (Goudappeltje 100% Puur sap,
Appelsientje®) contains juice from the concentrate of seven apples per litre
and is shortly heated to allow long storage. Fruct
1,3,4,5,6-pentahydroxyhexan-2-one)
molecular weight
180.15588 g/moll) is a monosaccharide and produced as white crystals or powder,
with a sweet taste and no objectionable odours. In solution, fructose is
colourless, odourless, and
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age >= 18 years. Body mass index (BMI) >=18.5 kg/m2 and
Exclusion criteria
Exclusion criteria: - Pregnancy. - Drugs and/or alcohol abuse. - Diagnosis of diabetes mellitus. - (History of) gastrointestinal and/or liver disease. - (History of [
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the fructose peak, defined as the maximal incremental change from baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include: 1. Systolic and diastolic blood pressure peak, defined as the maximal incremental change from baseline. 2. Serum uric acid peak, defined as the maximal incremental change from baseline. | — |
Countries
Netherlands
Outcome results
None listed