Duodenum weefsel duodenal tissue acquisistion obtaining gut tissue
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients are eligible, when they are already scheduled to undergo an upper gastrointestinal interventional endoscopy under deep sedation (propofol) at the Amsterdam UMC.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Previous GI surgery that could affect the ability to reach the duodenum via endoscopy, such as Bilroth 2, Roux-en-Y gastric bypass, or other similar procedures or conditions - History of duodenal inflammatory diseases including Crohn*s Disease and Celiac Disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of acquiring adequate histological samples, including - Endoscopic cold snare biopsy of duodenal tissue - Fixation of the specimens - Slicing and staining of the samples Ability to acquire adequate orientation of the tissue slides of the duodenal mucosa, in order to - Measure length of villi and crypts - Measure thickness of the mucosal layers - Determine density of certain stained cells/proteins. Size and depth of cold snare biopsy tissue slides of the duodenal mucosa. Weight of the cold snare tissue. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed