vroeggeboorte inflammatory bowel disease intestinal inflammation and injury
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 15 Years
Inclusion criteria
Inclusion criteria: NEC group: Preterm born children treated (surgically or conservatively) for necrotizing enterocolitis Bell*s stage II or III in the Erasmus MC-Sophia Children*s Hospital after January 1, 2008; Corrected age 6-15 years; Informed consent from parents/caregivers Control group: Preterm born children admitted to the NICU of the Erasmus MC - Sophia Children*s Hospital after January 1, 2008; Corrected age 6-15 years; Informed consent from parents/caregivers
Exclusion criteria
Exclusion criteria: NEC group: Focal intestinal perforation solely instead of NEC; Insufficient understanding of the Dutch or English language; Severe intellectual disability (defined as unable to cooperate in the performed tests); Severe motor disability (defined as unable to determine the child*s reaction time prior to the thermal sensitivity assessment) Control group: In addition to the exclusion criteria mentioned above, diagnosis of necrotizing enterocolitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study has two primary endpoints: the between group difference in Short Sensory Profile score and the between-group difference in heat pain sensitivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, we will assess the between-group differences in heat detection, cold detection, cold pain sensitivity, mechanical detection, mechanical pain sensitivity, behaviour, executive function, chronic pain, and (health-related) quality of life and we will assess cosmetic outcome of and satisfaction with the scar in surgically treated NEC patients. | — |
Countries
Netherlands
Outcome results
None listed