The effect of acute ketone monoester supplementation on glucose oxidation during exercise performed with high rates of carbohydrate ingestion in trained cyclists

The effect of acute ketone monoester supplementation on glucose oxidation during exercise performed with high rates of carbohydrate ingestion in trained cyclists - Ketone study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON53385

Enrollment

Registered

2023-05-03

Start date

2024-03-04

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This study will evaluate the effect of exogenous ketone mono-ester supplementation on endogenous and exogenous carbohydrate metabolism during exercise energy metabolism

Interventions

The acute interventions will involve ingestion of carbohydrates with either a ketone monoester supplement before (0.35 g/kg body mass) and throughout (0.20 g/kg body mass per hour) the 3-hour exerci

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - 18-50 years of age - Trained cyclist/triathlete ((VO2peak > 55 ml/kg/min for males and >48 ml/mg/min for females) - Healthy as per medical history and investigator*s/physician*s judgement - Having given written informed consent

Exclusion criteria

Exclusion criteria: - Use of medication that could impact study outcomes and/or interfere with the expected mechanism of action of ketone supplements (e.g. Chronic use of gastric acid suppressing medication, statins, corticosteriods) - Smoking - Diagnosed acute or chronic medical conditions that, in the opinion of the investigator, could impact study outcomes (e.g. Diabetes mellitus) - Diagnosed musculoskeletal disorders - Adhering to a carbohydrate restrictive diet - Participation in another study at the same time - Blood donation in the 2 months before the first experimental trial - Plasma donation in the 2 weeks before the first experimental trial - Males: VO2peak

Design outcomes

Primary

Measure	Time frame
Comparing exogenous glucose oxidation during exercise between the ketone monoester and placebo conditions	—

Secondary

Measure	Time frame
- Endogenous glucose disappearance rate - Exogenous glucose disappearance rate - Total glucose disappearance rate - Exogenous glucose appearance rate - Endogenous glucose appearance rate - Total glucose appearance rate - Plasma glucose enrichments Tertiary - Total carbohydrate oxidation indirectly by using traditional stoichiometric calculations of carbohydrate oxidation - Plasma glucose, insulin, lactate, glycerol, and ketone body concentrations (including area under the curve) following drink ingestion - Exercise economy - Mean exercise heart rate - Data for subject characteristics (i.e. age, weight, height, peak oxygen uptake)	—

Measure

Time frame

- Endogenous glucose disappearance rate - Exogenous glucose disappearance rate - Total glucose disappearance rate - Exogenous glucose appearance rate - Endogenous glucose appearance rate - Total glucose appearance rate - Plasma glucose enrichments Tertiary - Total carbohydrate oxidation indirectly by using traditional stoichiometric calculations of carbohydrate oxidation - Plasma glucose, insulin, lactate, glycerol, and ketone body concentrations (including area under the curve) following drink ingestion - Exercise economy - Mean exercise heart rate - Data for subject characteristics (i.e. age, weight, height, peak oxygen uptake)

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)