Cardiac and intramuscular adaptations following short-term exercise prehabilitation in unfit patients scheduled to undergo hepatic or pancreatic surgery

Cardiac and intramuscular adaptations following short-term exercise prehabilitation in unfit patients scheduled to undergo hepatic or pancreatic surgery - CIRCULATE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53378

Enrollment

Registered

2023-06-30

Start date

2024-03-06

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatopancreatobiliary malignancies liver pancreas and bile duct tumours

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - VO2 at the ventilatory anaerobic threshold (VAT)

Exclusion criteria

Exclusion criteria: - Patients requiring acute (emergency) surgery; - Patients not capable of cycling on a cycle ergometer; - Patients with contraindications to physical exercise training; - Patients receiving neoadjuvant chemotherapy - Contraindications for exCMR (e.g., claustrophobia, implanted cardiac devices) - Atrial fibrillation or other significant arrhythmia during the exCMR and 31P-MRS procedures; - Body weight >140 kg; - Body length > 190cm - History of myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft

Design outcomes

Primary

Measure	Time frame
The difference in left and right ventricular function will be measured by exCMR in rest, during progressive exercise, and recovery to assess the effect of the preoperative physical exercise training program on cardiac function. The difference in quadriceps phosphocreatine concentration (PCr), quadriceps inorganic phosphorus concentration (Pi), and quadriceps pH at rest, during progressive exercise, and recovery rate will be measured by 31P-MRS to assess the effect of the prehabilitation program on skeletal muscle function.	—

Measure

Time frame

The difference in left and right ventricular function will be measured by exCMR in rest, during progressive exercise, and recovery to assess the effect of the preoperative physical exercise training program on cardiac function. The difference in quadriceps phosphocreatine concentration (PCr), quadriceps inorganic phosphorus concentration (Pi), and quadriceps pH at rest, during progressive exercise, and recovery rate will be measured by 31P-MRS to assess the effect of the prehabilitation program on skeletal muscle function.

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Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results