cardiac arrest post anoxic coma
Conditions
Interventions
The intervention period will commence at the time of randomisation. Rapid
cooling in the
hypothermia group will be achieved by means of cold fluids and state-of-the-art
cooling devices
(intravascula
cardia arrest
hypothermia
neuroprotection
Sponsors
Dept of anaestesia and intensive care, Helsingborg Hospital
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1) Age 18 years, 2) Out of hospital cardiac arrest of presumed cardiac cause, 3) Sustained return of sponteneous circulation (ROSC), 4) Unconsciousness (GCS
Exclusion criteria
Exclusion criteria: * Known limitations in care or a Do not resuscitate (DNR)-order * Known disease making 180 day survival unlikely * Temperature on admisison
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to determine if hypothermia (33°C) increases 180 day survival when compared to normothermia and early treatment of fever, in patients who are unconscious after OHCA. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate if there is any difference in functional outcomes, using the Glasgow Outcome Scale-extended (GOS-E) between patients managed at 33°C compared to normothermia and early treatment of fever. GOS-E will be assessed at 180 days and at 24 months. * To evaluate potential differences in health-related quality of life (HRQoL) at follow up using EQ5D-5L at 180 days and at 24 months. * Time-to-event (survival). All patients will be followed until the last included patient has been followed-up at 180 days. If death has not occurred patients will be censored at this point. | — |
Countries
The Netherlands
Outcome results
None listed