normal brain function normal brain function
Conditions
Interventions
Participants receive TUS targeting the amygdala/mediodorsal thalamus/pulvinar
thalamus.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Between 18-40 years of age; - The ability and agreement to provide informed consent in sound body and mind, and the ability to fulfil the study*s requirements.
Exclusion criteria
Exclusion criteria: • Under 18 years of age; • Current pregnancy; • Claustrophobia; • A history or brain surgery or serious head trauma; • A history of or any close relatives (parents, siblings, children) with epilepsy, convulsion, or seizure; • Predisposition for fainting spells (syncope); • A cardiac pacemaker or intra-cardiac lines; • An implanted neurostimulator; • Implanted medication infusion device; • Implanted metal devices or large ferromagnetic fragments in the head or upper body (excluding dental wire), or jewellery/piercing that cannot be removed; • Use of a medical plaster that cannot or may not be taken off (e.g., nicotine plaster); • Cochlear implants; • Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.); • Diagnosed neurological or psychiatric disorders; • Use of psychoactive (prescription) medication (excluding anti-conception); • Skin disease at intended stimulation sites; • The consumption of more than four alcoholic units within 24 hours before participation • The consumption of recreational drugs within 48 hours before participation; • Calcifications in the brain. • All other criteria relevant to non-invasive brain stimulation as reported in the Donders Standard Operating Procedures for Non-Invasive Brain Stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrinsic functional connectivity profiles and task sensitivity of the target regions (amygdala, mediodorsal thalamus, pulvinar thalamus) are the primary dependent measures that will be used to assess TUS target engagement. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will test the activation of the mediodorsal thalamus and pulvinar thalamus when a flexible processing task engages these regions. | — |
Countries
Netherlands
Contacts
Public ContactCE Evans
Radboud Universiteit Nijmegen
Outcome results
None listed