hersenaandoening Alzheimer's disease dementia
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the inclusion all of the following criteria. For this study three different routes for inclusion exists. Inclusion criteria for each group separately are shown below.: 1. Participants who were included in our previous CASCADE study (P19.039). * Capable of giving informed consent (see appendix) 2. Patients who attended the memory clinic of the Leiden University Medical Center/ Haaglanden MC within one year ago • Diagnosed with (mixed) probable AD • Diagnosed as MCI • Diagnosed as SCI • Age between 50-90 years • Capable of giving informed consent (see appendix) 3. Control subjects • Healthy adults without memory complaints • Age aged between 50-90 years old • Capable of giving informed consent
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study. For this study three different routes for inclusion exists. Exclusion criteria for each group separately are shown below. 1. Participants who were included in our previous CASCADE study (P19.039). • No MRI at previous CASCADE study (P19.039) 2. Patients who attended the memory clinic of the Leiden University Medical Center/Haaglanden MC within one year ago - Contra-indication to MRI scanning: • Claustrophobia • Pacemakers and defibrillators • Nerve stimulators • Intracranial clips • Intraorbital or intraocular metallic fragments • Cochlear implants • Ferromagnetic implants • Hydrocephaluspump • Intra-utrine device (not all types) • Permanent make-up • Tattoos above the shoulders (not all) - Specific contraindications to fMRI • Seizure within prior year. • Noncorrectable visual impairment. - MMSE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) 3T MRI: the amplitude of the BOLD response in percentage signal change between stimulus on and off, time-to-peak response (sec), and time-to-baseline (sec) after discontinuation of the visual stimulus, classic signs of CAA (intracranial hemorrhage, lobar microbleeds, subarachnoidal hemorrhage and superficial siderosis) and SVD markers (number of small subcortical infarcts and lacunes, volume of white matter hyperintensities (WMHs), perivascular spaces in the basal ganglia and centrum semiovale, number and location of deep microbleeds and grey matter volume). 2) Neuropsychological assessment 3) Baseline characteristics, 4) DNA: APOE * genotype. | — |
Countries
Netherlands
Outcome results
None listed