Lassa Virus Infection viral hemorrhagic fever
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Written informed consent to store samples and perform genetic testing. - Age >= 18 years - Individuals who have experienced PCR proven LASV infection and minimally 4 weeks post-infection
Exclusion criteria
Exclusion criteria: - Mental disorder that in the view of the investigator would interfere with adherence to the treatment or the study procedures, or the decision to participate in the study. - Immunosuppressive medication or other diseases associated with immunodeficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutralization potency and breadth of monoclonal antibodies derived from LASV individuals who have recovered from LASV infection as assayed in neutralization assays using lentiviral vectors pseudo-typed with Lassa GP protein | — |
Secondary
| Measure | Time frame |
|---|---|
| - Percentage Lassa GP positive memory B cells as assayed by FACS (clonality) using Lassa GP protein labelled in different colors - Sequence screening of the most promising LASV monoclonal antibodies | — |
Countries
Netherlands
Outcome results
None listed