blood poisoning infection infectious disease Sepsis
Conditions
Interventions
Patients will be randomized to one of two groups.
Group 1 (Control group): standard intravenous antibiotic therapy based on
current clinical guidelines and practice. Standard therapy will include TD
Prediction
Antibiotics
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age >18 years - Suspected / confirmed infection - Suspected / confirmed lactate concentration > 2 mM OR treatment / imminent treatment with vasopressors - Treatment / imminent treatment with one or more of the following antibiotics: vancomycin, ceftriaxone, meropenem, ciprofloxacine, cefotaxime.
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PK target attainment in the first 24-hours. Targets are 100%-fT>4MIC for the beta-lactam antibiotics, AUC/ MIC>400 for vancomycin and fAUC/MIC *125 for ciprofloxacin. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to PK target level, PK target attainment during therapy, attainment of clinical cure, length of ICU and hospital stay, delta Sequential Organ Failure Assessment (SOFA) score at 96 hours, days free of ventilator / hemofiltration / other organ support, ICU / hospital / 28 day / 6-month mortality, quality of life at hospital discharge (EQ-5D-5L) and after 6 months, societal costs (iMTA MCQ and iMTA PCQ after 6 months), days free of delirium. We will assess physician compliance and satisfaction with AutoK and investigate whether its use is associated with an increase in PK/PD knowledge amongst healthcare workers. | — |
Countries
The Netherlands
Outcome results
None listed