atrial fibrillation palpitations
Conditions
Interventions
After verifying adequate quality of the DE-MRI study, subjects will be
randomized to one of two study groups to receive conventional PVI ablation
(Group 1) or PVI + fibrosis-guided ablation (Group 2
ablation
atrial fibrillation
cardiac arrhythmias
Sponsors
University of Utah health Sciences Center
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Patients with persistent AF undergoing first AF ablation as per recent HRS consensus document. Persistent AF is defined by 7 days or more in AF as evidenced by either 1) rhythm strip or 2) written documentation. - Must have some proportion of atrial fibrosis (not limited to advanced stage fibrosis). - Able to understand and willing to sign the Informed Consent Form. - Age * 18 years.
Exclusion criteria
Exclusion criteria: - Contraindication for DE-MRI with a full dose of Gadolinium-based contrast agent. - Previous left atrial ablation or surgical procedure. - Women currently pregnant. - Mental or physical inability to take part in the study. - Uncontrolled hypertension. - Inability to be placed in MRI due to body mass.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To examine the efficacy of targeting atrial fibrosis tissue during an ablation procedure in treating persistent AF. The frequencies and proportions of patients experiencing each of three components of the primary AA outcome: atrial fibrillation atrial flutter atrial tachycardia | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life as measured by the Toronto Score. A composite outcome including AA recurrence and prescription of an anti-arrhythmic medication, stroke, cardiovascular hospitalization, a repeat ablation, AA recurrence following repeat ablation | — |
Countries
The Netherlands
Outcome results
None listed