Liver cirrhosis liver scarring
Conditions
Interventions
Patients will participate in a home-based bimodal lifestyle program. The
program comprises semi-supervised high intensity interval and endurance
training on an advanced cycle ergometer (Lode Corival
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Diagnosed with end-stage liver disease / liver cirrhosis (regardless of etiology); • On the waiting list for OLT; • VO2 at the VAT
Exclusion criteria
Exclusion criteria: • Experienced a MACE (e.g., myocardial infarction) in the past six months; • Experienced a cerebrovascular incident in the past six months; • Medical history of an uncontrolled heart rhythm disorder; • Hepatic encephalopathy grade 3 or 4; • Acute liver failure; • Acute on chronic liver failure; • Hospitalization at start of the study; • Non-treated esophageal varices (i.e., variceal eradication endoscopy and/or adequately dosed NSBB); • Not capable of cycling on a cycle ergometer • No available community physical therapist in the living area of the patient. Patients refusing or unable to sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter/endpoint is the progression in aerobic capacity after 6 weeks. Hereto, before and after the first training period a CPET will performed to determine the difference in VO2 at the VAT and VO2peak in ml/kg/min. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary parameter/endpoint of this study is the progression in aerobic capacity after the second training period, and six weeks after termination of the program. Hereto, after 12 and 18 weeks another CPET will be performed. Other secondary parameters/endpoints are the evaluation of differences in sarcopenia, anthropometry, functional mobility, quality of life, perceived fatigue, incidence of hepatic encephalopathy, number of unplanned hospital admissions, change in liver frailty index score and change in microbiome composition at six, 12 and 18 weeks, or until transplantation. Furthermore, postoperative outcomes up to twelve months post-OLT will be collected. | — |
Countries
Netherlands
Outcome results
None listed