Intoxication and poisoning
Conditions
Interventions
Volunteers will receive two 500 mg paracetamol tablets orally in the fasting
state. If early data analyses are successful, the volunteers will receive one
500 mg paracetamol tablet in the fasting st
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age between >= 18 and
Exclusion criteria
Exclusion criteria: Known substance abuse, psychotic disorders, and/or other diseases expected to interfere with the study or the patient*s safety. A body weight 1.0) In case of being in a dehydrated state In case of chronic undereating Administration of paracetamol within 1 week before start of the study intervention Known allergy to paracetamol Alcohol intake 24 hours before paracetamol administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is a difference in the intensity of GC-MS variables (M/Z ratio's at a specific retention time) between time points before and after paracetamol intake, determined via non-parametric univariate paired tests (Wilcoxon signed rank). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint is the association between concentrations of paracetamol in the saliva and the obtained multivariate models and retaining univariate ion fragments via ANCOVA. | — |
Countries
Netherlands
Outcome results
None listed