ReachPR Trial: Restoration of AV coupling by Cardiac Resynchronization Therapy in heart failure patients with prolonged PR interval

ReachPR Trial: Restoration of AV coupling by Cardiac Resynchronization Therapy in heart failure patients with prolonged PR interval - ReachPR Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON53332

Enrollment

Registered

2017-12-14

Start date

2018-06-18

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

Extra hemodynamic measurements will be performed during CRT implantation (invasive) and after approximately one to two weeks (echocardiographic protocol).

Atrioventricular dyssynchrony

Cardiac resynchronization therapy

Heart failure

Prolonged PR interval

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Indication for an ICD device according to current guidelines; - Stable prolonged PR interval >230ms; - Reduced LVEF (

Exclusion criteria

Exclusion criteria: - Already implanted with an CRT device; - Resting Heart rate >90 bpm; - LBBB QRS morphology; - QRS duration >150ms - Recent myocardial infarction (within 40 days prior to enrolment); - Second or third degree AV block; - Life expectancy

Design outcomes

Primary

Measure	Time frame
The acute hemodynamic changes in LV stroke work (SW) during AV optimization by atrio-biventricular pacing.	—

Secondary

Measure	Time frame
- The acute hemodynamic changes in LV dP/dt\|max and LV stroke volume (SV) by invasive measurements during AV optimization by atrio-biventricular pacing. - The acute hemodynamic changes in LV stroke volume (SV), diastolic mitral regurgitation and LV diastolic filling time by echocardiography during AV optimization by atrio-biventricular pacing.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)