Major Depressive Disorder
Conditions
Interventions
During all three phases participants will receive CAU, weekly sessions (60
minutes) according to the Multidisciplinary Guidelines for Depression -
Addendum Youth. During phase B (intervention phase)
Sponsors
GGZ Oost Brabant (Rosmalen)
Eligibility
Age
16 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Adolescents aged between 16 and 23 years in care at GGZ Oost Brabant • Mastery of Dutch language • Moderate to severe depression after 3 months of Care As Usual (CAU) for depression: o Score > 26 on the IDS-SR (Bernstein et al., 2007) o DSM-5 diagnosis of depression, confirmed with the MDD part of the Mini International Neuropsychiatric Interview - Simplified (MINI-S), Dutch version 1.1. for DSM-5 (Overbeek & Schruers, 2019). • Moderate to severe childhood trauma (CT) before the age of 16 o At least one score above validated cut-offs for the CT subtypes of the Childhood Trauma Questionnaire - Short Form (CTQ-SF; Bernstein & Fink, 1998; physical neglect: score >10; emotional neglect: score >15; sexual abuse: score >8; physical abuse: score >10; emotional abuse: score >13) • In the case of suicidal ideation: The patient is in possession of an up to date safety plan • Patient is inclined to give written informed consent
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • There is still immediate physical threat/harm/violence in the adolescent*s life which acquires attention i• There is a history of trauma-focused therapy with EMDR, imagery exposure or Imagery Rescripting in regard to the traumatic childhood event • There is alcohol/drug dependence or other sever psychiatric comorbidity (e.g. bipolar disorder, psychotic disorder) that requires clinical attention • There is a primary DSM-5 diagnosis of PTSD or Acute Stress disorder (ASD) • There is acute suicide risk with an indication for hospitalization (further elaborated in the research protocol p.18)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is defined as depression symptom severity measured with the self-report PHQ-9 three times a week during all phases and measured with the IDS-SR at four time points: before phase A1, between phase A1 and phase B, between phase B and phase A2, and after phase A2. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are depression diagnosis and PTSD-diagnosis assessed with a structured interview held at the start and at the end of the study. The level of distressing mental images, suicidal ideation, post-traumatic stress symptoms, resilience are measured at the four time points as described above. | — |
Countries
Netherlands
Outcome results
None listed