essential tremor trembling
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of essential tremor - Age of 18 years or older
Exclusion criteria
Exclusion criteria: - Pregnancy - History of (previous) alcohol misuse - Medication incompatible with alcohol intake - No alcohol consumption in the previous year - MR contra-indications. Presence of MR-incompatible metals for instance after surgical procedures may be verified with a single X-ray if clinical documentation is insufficient. For participants with essential tremor: - (Very) mild tremor For healthy participants: - A first degree relative with essential tremor. - Cognitive impairments defined as MoCA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tremor related brain activation will be investigated with EMG and accelerometry, as a measure for tremor, and fMRI, as a measure for brain activity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters apart from EMG-fMRI: - Resting state fMRI - Task based fMRI (non-EMG) - Anatomical MRI - MoCA scores as covariate Secondary study parameters related to measures of alcohol responsivity include: - Bain Findley Spirographs - Fahn-Tolosa-Marina Essential Tremor Rating Scale, part A, B and C, as a comprehensive measure of baseline tremor severity - Visual Analogue Scale, as a patient-based measure of tremor severity - Blood alcohol level measured with a breath analyser | — |
Countries
Netherlands
Outcome results
None listed