Cardiometabolic and chronic respiratory diseases Heart disease, metabolic diseases and chronic lung diseases
Conditions
Interventions
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Aged 30-55 years; - Residing in (the vicinity of) Amsterdam or Hoorn; - Able to provide written informed consent; - Understanding of the Dutch language.
Exclusion criteria
Exclusion criteria: - Unable to give written informed consent; - Serious mental impairment, i.e., preventing to understand the study protocol/aim.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - The prevalence of (pre) type 2 diabetes - The 5-year incidence rate of (pre) type 2 diabetes - The prevalence of chronic lung diseases - The 5-year incidence rate of chronic lung diseases - (Change in) lung damage assessed by CT scans, only in the subgroup (n = 350) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Lung function - Medication use - Blood pressure - Respiratory complaints (including dyspnea) - Psychological complications - Quality of life - Occurrence of cardiovascular disease - All-cause and cause-specific mortality - Fatigue - Anthropometrics - Dietary intake - Physical activity - (Change in) exhaled breath profile - (Change in) transcriptome, genome, epigenome, metabolome and microbiome - Residential environmental exposures, including ambient air pollution and green space - Subjective environment and the use of green spaces - Personal exposome measurements (only in subgroup of 350 participants) - Willingness to participate in a combined lifestyle intervention (only in subgroup of 350 participants) - Reasons for non-participation in the CooL program (only in participants of the subgroup fulfilling the CooL eligibility criteria) and evaluation of the experiences of participation in the CooL program | — |
Countries
Netherlands
Contacts
Public ContactL.D. Bloemsma
Amsterdam UMC
Outcome results
None listed