Eiwitbehoefte Protein requirement
Conditions
Interventions
Subjects will undergo two test days in randomized order during which they
receive either enteral feeding according to a standard protein dose (1.3
g/kg/d) or a higher protein dose (2.0 g/kg/d). Cont
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • >= 18 years old • Unplanned admission to the ICU • Mechanically ventilated • Start of enteral nutrition within 2 days of intubation • >= 3 days on enteral nutrition • Expected remaining ICU stay on mechanical ventilation of >= 2 days
Exclusion criteria
Exclusion criteria: • Contra-indication for enteral nutrition at the discretion of the treating physician • Feeding intolerance during incremental feeding protocol • Moribund or withholding of treatment • On extracorporeal membrane oxygenation (ECMO) • Presence of chest drains, pneumothorax, tracheoesophageal fistula or subcutaneous emphysema • Kidney failure AND a *no dialysis*-code on admission • Hepatic encephalopathy (West Haven criteria 3-4) • BMI < 18 kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is indicator amino acid oxidation after enteral feeding with a standard or higher protein content, determined using the Indicator Amino Acid Oxidation (IAAO) method by measuring 13CO2 enrichment in expired breath and enrichment of L-[1-13C]-phenylalanine in plasma and urine. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine carbon dioxide production, 13CO2 production, plasma and urine L-[1-13C]-phenylalanine enrichments, plasma phenylalanine concentration, and fecal output and protein content in ICU patients when applying the IAAO technique. | — |
Countries
Netherlands
Outcome results
None listed