'Exercise Induced Laryngeal Obstruction (EILO)' "Glottic or supraglottic narrowing of the airway during exercise"
Conditions
Interventions
Continuous laryngoscopy during exercise
Sponsors
Medisch Spectrum Twente
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: -Age 8 to 18 years old -Outpatient at Medisch Spectrum Twente or Haukeland University Hospital -History of paediatrician diagnosed asthma confirmed with objective lung function measurements: -a positive test for exercise induced bronchoconstriction (post-exercise fall in FEV1 > 10% after exercise challenge test) OR -a positive methacholine test (PC20 value of =12% and/or >=200 mL following inhalation of 400 µg SABA )
Exclusion criteria
Exclusion criteria: -Other severe cardiopulmonary disease than asthma -Inability to perform exercise test and/or technical acceptable spirometry -Current asthma exacerbation, or exacerbation in the previous 2 weeks -Respiratory tract infection in the previous 2 weeks -Use of LABA or SABA less than 8 hours prior to exercise challenge test -Use of oral corticosteroids in 4 weeks prior to exercise challenge test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of EILO based on the Maat score (glottic and/or supraglottic, grade 2 or higher) during the CLE test | — |
Secondary
| Measure | Time frame |
|---|---|
| -Recognizable symptoms induced : yes/no -EILO grade score (Maat score; glottic and/or supraglottic) -Laryngeal pathology at rest -Exercise induced bronchoconstriction defined as post-exercise fall in FEV1 > 10% during CLE test and during ECT beforehand. (Post-exercise fall in FEV1 = (FEV1pre-exercise - FEV1post-exercise) / FEV1pre-exercise * 100%). -Symptoms reported -Test duration and duration until start of symptoms and until peak dyspnea -Heart rate during exercise -Lung function with in- and expiratory flow volume loops (FEV1, FEV1(%pred), FVC) -before exercise -after exercise at 2 minute intervals (1,3,6 minutes) -Maximum running pace and slope (or max Wattage and Wattage/kg ) -ACT score and sub scores -EILODI score and sub scores -VAS score: before exercise, at peak level of dyspnea and 2 minutes after exercise | — |
Countries
Netherlands
Outcome results
None listed